Metabolomics: Approaches and Applications to Diabetes Research
نویسندگان
چکیده
منابع مشابه
Metabolomics Applied to Diabetes Research
Type 2 diabetes is caused by a complex set of interactions between genetic and environmental factors. Recent work has shown that human type 2 diabetes is a constellation of disorders associated with polymorphisms in a wide array of genes, with each individual gene accounting for 1% of disease risk (1). Moreover, type 2 diabetes involves dysfunction of multiple organ systems, including impaired ...
متن کاملMetabolomics and Diabetes: Analytical and Computational Approaches
Diabetes is characterized by altered metabolism of key molecules and regulatory pathways. The phenotypic expression of diabetes and associated complications encompasses complex interactions between genetic, environmental, and tissue-specific factors that require an integrated understanding of perturbations in the network of genes, proteins, and metabolites. Metabolomics attempts to systematical...
متن کاملMetabolomics and Cell Therapy in Diabetes Mellitus
Diabetes with a broad spectrum of complications has become a global epidemic metabolic disorder. Till now, several pharmaceutical and non-pharmaceutical therapeutic approaches were applied for its treatment. Cell-based therapies have become promising methods for diabetes treatment. Better understanding of diabetes pathogenesis and identification of its specific biomarkers along with evaluation ...
متن کاملComputational Approaches to Metabolomics: an Introduction
This marks the first time that the Pacific Symposium in Biocomputing has hosted a session specifically devoted to the emerging computational needs of metabolomics. Metabolomics, or metabonomics as it is sometimes called, is a relatively new field of “omics” research concerned with the high-throughput identification and quantification of the small molecule metabolites in the metabolome (i.e. the...
متن کاملTargeted Metabolomics Finds Its Mark in Diabetes Research
Numerous biochemical pathways are deranged in diabetes, especially those involving metabolic fuels. Metabolomics, which seeks to simultaneously measure many small molecules, shows promise as a source of mechanistic insight into the molecular pathology of diabetes (1), but no systematic approach has yet come into wide use. Methods vary greatly from laboratory to laboratory. For most of the last ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Diabetes & Metabolism
سال: 2013
ISSN: 2155-6156
DOI: 10.4172/2155-6156.s6-001